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Overall, 14 of 16 patients reported pain relief. Promising human signal? Yes. Proof that it works? Not without a legit randomized controlled trial. I would love to see a trial comparing the

Karampitsakos T, Akinosoglou K, Papaioannou O, Panou V, Koromilias A, Bakakos P, et al

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Figure 1 2 Providing increasing doses of LT4 therapy The optimal treatment for hypothyroidism remains a subject of debate, with the etiology and severity of hypothyroidism and the amount of residual functional thyroid tissue affecting the LT4 dosage ( DIO2 gene—particularly the common Thr92Ala variant—have been associated with altered enzymatic function and reduced intracellular T3 availability in key tissues, despite normal serum TSH and FT4 levels ( PDE8B ) gene, which encodes a high-affinity cAMP-specific phosphodiesterase, as genetic modulators of TSH levels ( 3 LT4+LT3 combination therapy When monitoring the efficacy of LT4 therapy, adequacy is traditionally assessed by TSH and FT4 levels