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Active secretion of HMGB1 from localised activated microglia and astrocytes readily increase the pool of this key DAMP [18], thereby creating neurotoxic feedback loop driving downstream ictogenic effects such as modulating synaptic plasticity, increasing blood brain barrier permeability and enhancing mossy fibre spouting [52]
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Design, synthesis, and biological evaluation of nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation
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