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High T3 levels are related to increased myocardial contractility and electrical conduction, and arrhythmias events, while low T3 promotes opposite effects, such as bradycardia ( The heart is able to locally adjust the metabolism of TH through the modulation of D3 activity, as described in myocardial infarction (76) and dilated cardiomyopathy (77)
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Curcumin analog ALZ003 can induce ubiquitination degradation of androgen receptor and significantly increase the sensitivity of GBM cells to temozolomide both in vitro and in vivo, and the mechanism may be related to ROS accumulation, lipid peroxidation and inhibition of GPX4, which are major features of ferroptosis
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