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The NAD+ Salvage Pathway and Energy Expenditure When NNMT is inhibited by 5-Amino-1MQ, the rescued nicotinamide is funneled directly into the NAD+ salvage pathway via the rate-limiting enzyme Nicotinamide Phosphoribosyltransferase (NAMPT)

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However, GSH is found in intracellular organelles including endoplasmic reticulum (ER), nucleus, and mitochondria to control compartment-specific needs and functions (Mari et al., 2009, 2010)