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14,15 This direct relativistic contraction effect is orchestrated by relativistic perturbation operators that impact the regions of the nucleus and simultaneously affect the density of s -electrons within the valence shell, leading to an increase in the square of the nuclear charge (Z)

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It has also been proposed that NKCC1 and SUR1-regulated TRPM4 channel act synergistically in the injured CNS, and that combination therapy directed against these two targets should be more efficacious than a single-target approach [220]

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