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Second, taken into account that the activity of the distinct elements of the pathogenic scenario may vary from patient to patient, and even in the single patient at different stages of the disease, the identification of multiple biomarkers to reclassify patients according to disease activity is of paramount importance to treat the right patients with the right drugs combination

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6-An does not affect G6PD, but instead, blocks 6PGD( in vivo studies revealed that 6-An inhibits the carbon-atom transfer from glucose to ribose and suppresses oxPPP ( in vitro ( Additional drugs have been identified to inhibit the enzymatic activity of G6PD