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Environmental Substances Associated with Neurodegeneration: An Overview of Parkinson's Disease and Related Genotoxic Endpoints
ROS levels are increased and drive the acquisition and/or maintenance of the senescent phenotype ( DNA oxidation can trigger the activation of the DDR, an essential mechanism for the induction and establishment of senescence ( Senescent cells also present changes in antioxidant systems, that contribute to the alteration in redox homeostasis, and metabolomic studies have provided interesting insights into glutathione metabolism in this setting
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