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Compared to open-flap debridement procedures, BMP-2 promoted defect healing while reducing both the gain in clinical attachment levels and reduced pocket depth, making it a promising alternative to traditional grafts [447]

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It increases collagen and glycosaminoglycan production, promotes new blood vessel growth (VEGF / angiogenesis), dampens NF-κB-driven inflammation, raises antioxidant enzymes (glutathione, SOD, ascorbate), and modulates the expression of more than 4,000 human genes toward a more youthful, regenerative profile (Pickart et al., BioMed Research International, 2015)