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▪ Functions of IDH and 2HG The family of IDH enzymes includes three isoforms: IDH1, which is located in the cytoplasm, and IDH2 and IDH3, which localize in mitochondria ( Figure 1 )

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For example, iron is involved the formation of the iron porphyrin complex known as heme, and other roles played by iron depend largely on its highly efficient electron transfer properties, which enable it to donate or accept electrons and thus act as a catalytic cofactor in various biochemical reactions

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