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In addition to specific inborn errors of metabolism that cause LoF in seven ALDH family members, 23 – 27 other sources of aldehydes include those generated by ROS-induced peroxidation of lipids, 3 ROS-induced glycoxidation of carbohydrates, 3 genetic mutations that sabotage the normal cellular protection mechanisms that neutralize aldehydes, 3 genetic mutations related to the heritable forms of alcoholism, 19 , 130 , 131 and possibly aldehydes generated by abnormal gut microflora