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each R 2 is independently selected from small molecule USP2 inhibitors comprises Formulae (I-A-3), (I-A- 4) and (I-A-5): Formula (I-A-3), Formula (I-A-4), Formula (I-A-5), wherein each R 11 is independently selected from H, halogen, cyano, OR 6 , NR 6 R 7 , C(O)OR 8 , C(O)NR 8 R 9 , S(O) 2 NR 8 R 9 , C 1 -C 6 alkyl, C 1 -C 6 heteroalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 12 cycloalkyl, 3-12 membered heterocyclic, C 6 -C 10 aryl, or 5-10 membered heteroaryl, where each said C 1 -C 6 alkyl, C 1 -C 6 heteroalkyl, C 2 -C 6 alkenyl, C 2 - small molecule USP2 inhibitors comprises Formulae (I-A-6), (I-A- 7) and (I-A-8): Formula (I-A-6), Formula (I-A-7), Formula (I-A-8), wherein R 1 , n and m are defined in Formula (I)