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Summary Keywords G protein-coupled receptors, cyclic AMP, cAMP efflux, adenosine, adenosine receptors, ABC transporters, ecto-phosphodiesterase, ecto-5′-nucleotidase Citation Godinho RO, Duarte T and Pacini ESA (2015) New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway