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Notably, 4-HNE can activate the PPARγ pathway, suppressing PGC-1α-mediated mitochondrial biogenesis and reducing local ATP supply at synapses, thereby impairing plasticity mechanisms such as LTP (56) Simultaneously, the electrophilic properties of 4-HNE facilitate its formation of adducts with synaptic proteins (e.g., synapsin I, PSD-95), directly disrupting synaptic ultrastructure (194) https://cdn.thewellbio.com/wp-content/uploads/2026/01/CytoGrow-LR3-IGF1-Human-Recombinant-Protein-Bioactivity-800x387.png Esigenza_Donne Flavour:Juicy Orange Effects of losartan and candesartan on the serum levels of: A, alanine... | Download Scientific Diagram
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